This post is in active drafting. Slug live so cluster cross-links resolve. Full body shipping in the follow-up batch.
Outline
- The honeymoon is real. What's happening biochemically in weeks 1–3.
- Why the wow fades. Negative-feedback regulation of NAD synthesis, sirtuin downregulation, the precursor-pathway story.
- The four patients NAD IV actually helps long-term. Genuine NAD-pathway depletion, post-acute neurodegeneration, addiction recovery context, certain mitochondrial profiles.
- The four patients who waste their money. Mostly-well biohackers, fatigue without workup, anxiety presentations, autoimmune flares.
- The cheaper, smarter precursor approach. NMN, NR, niacinamide, sequencing.
- The Klinghardt read. NAD IV is a Level-1 tool. Most of the patients chasing it are stuck on Level 2 or Level 3. (5 Levels of Healing.)
- When we use it in clinic — and when we redirect.
Full body next batch. In the meantime, the related cluster posts cover the surrounding terrain.
High-intent questions
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